OFI defeated Panathinaikos, leaving them on the verge of exit from the Cup.
The midweek games had some other upsets like second division side Anagennisi Karditsas holding AEK to a draw, unlike what many expected.
Panathinaikos are on the brink of crashing out of the tournament after Olympiakos defeated Hania 4-0. The Greee giants had goals from Esteban Cambiasso, Brown Ideye and Felipe Pardo. Pantelis Theologou scored an own goal to complete the 4-0 rout.
Panathinaikos manager Andrea Stramaccioni left his role due to the poor result. Iraklis defeated Apollon Smyrnis 3-0 on Wednesday. This implies that Panathinaikos would exit the Cup in the group stage if Iraklis play a draw with OFI in the last round of games.
AEK also did not have a great game as they played a 2-2 draw at Anagennisi. Also, PAOK were forced to a draw by Trikala. The visitors could not score any goal as the game ended goalless.
Aiginiakos defeated Veria 1-0 to send them out from the Super League. The second division side from central Macedonia can progress. Kallthea defeated Atromitos 1-0 after they humbled PAOK 4-3 in the Super League.
Larissa edged Panelefsiniakos 2-1. Platanias scored just one goal but it was enough to earn them the maximum points against Sparti. Agrotikos and Astreras played a goalless draw.
In other games, Levadiakos defeated Panserraikos 3-1 while Panetolikos played a 1-0 with Panthrakikos. Kerjyra and Lamia played a 2-2 draw while Aris and Asteras played a 3-3 draw. Xanthi thrashed Kalloni Lesvou 3-1 while the game between Kissamikos and Panionios was postponsed due to poor pitch.